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UofC Department of Molecular Genetics and Cell Biology
Date Posted: October 2, 2009Application Deadline: December 31, 2009
Contact Information: Samuel Volchenboum, MD, PhD
773-769-7433
slv@uchicago.edu
Description:
Our group is working on developing algorithms to speed up and optimize data analysis from mass spectrometry experiments, focussing on spectrum-peptide matching algorithms. We recently published our initial findings, demonstrating our ability to deconvolute spectra based on pairing of spectra from isotopically labeled peptides. We now have an algorithm that obviates the need for traditional spectrum-searching methodologies. Currently, we are working to implement more complicated mathematical models for the purposes of combining and deconvoluting spectra. In addition, we are working to design modular software that harnesses these algorithms for the purpose of large-scale, near-real-time analysis of mass spectrometry data. An undergraduate student from the Department of Computer Science should find this to be an exciting and engaging project - both from the perspective of algorithm development as well as software design. We are currently in the process of collecting data and developing our second manuscript based on this work. We would love to engage a sufficiently motivated student to help us with our project - both in its current state and moving forward. If you are interested in joining us for a research project, please contact me directly.
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